![]() ![]() Atrial cardiopathy was defined as abnormal deep terminal negativity of the P wave in V1 (DTNPV1 = negative p-wave in V1<−100 µv), an electrocardiographic marker of atrial cardiopathy. This analysis included 8028 participants (60.0 ± 13.4 years, 51.9% women, 49.8% white) from the Third National Health and Nutrition Examination (NHANES III) Survey. To examine the association between atrial cardiopathy and stroke mortality. Prior studies examining the link between atrial cardiopathy and stroke risk have focused mainly on non-fatal stroke. © 2015 American Neurological Association. This association was limited to non-lacunar stroke (HR, 1.49 95% CI, 1.07-2.07) as opposed to lacunar stroke (HR, 0.89 95% CI, 0.57-1.40). In Cox regression models adjusted for potential confounders and incident AF, left atrial abnormality was associated with incident ischemic stroke (HR, 1.33 95% CI, 1.11-1.59). A higher incidence of stroke occurred in those with baseline left atrial abnormality (incidence rate per 1,000 person-years, 6.3 95% CI, 5.4-7.4) than in those without (incidence rate per 1,000 person-years, 2.9 95% CI, 2.7-3.1 P < 0.001). Outcomes were adjudicated ischemic stroke, non-lacunar (including cardioembolic) ischemic stroke, and lacunar stroke.ĭuring a median follow-up period of 22 years (interquartile range, 19-23 years), 904 participants (6.2%) experienced a definite or probable ischemic stroke. Left atrial abnormality was defined as PTFV1 >4,000 μV*ms. Our cohort comprised 14,542 participants 45-64 years of age prospectively enrolled in the Atherosclerosis Risk in Communities (ARIC) study and free of clinically apparent atrial fibrillation (AF) at baseline. We hypothesized that associations would be stronger with non-lacunar stroke, since we expected left atrial abnormality to reflect the risk of thromboembolism rather than in-situ cerebral small-vessel occlusion. To assess the relationship between abnormally increased P-wave terminal force in lead V1 (PTFV1 ), an electrocardiographic (ECG) marker of left atrial abnormality, and incident ischemic stroke subtypes. ![]()
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